Article
Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis.
Oncogene - 6 Mar 2003
Fujioka Shuichi, Sclabas Guido M, Schmidt Christian, Niu Jiangong, Frederick Wayne A, Dong Qiang G, Abbruzzese James L, Evans Douglas B, Baker Cheryl, Chiao Paul J
Abstract excerpt
We have demonstrated that nuclear factor-kappa B (NF-kappa B) is constitutively activated in human pancreatic adenocarcinoma and human pancreatic cancer cell lines but not in normal pancreatic tissues or in immortalized, nontumorigenic pancreatic epithelial cells, suggesting that NF-kappa B plays a critical role in the development of pancreatic adenocarcinoma. To elucidate the role of constitutive NF-kappa B...
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