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A φSa3int (NM3) Prophage Domestication in Staphylococcus aureus Leads to Increased Virulence Through Human Immune Evasion

1 Aug 2025

Abstract excerpt

ABSTRACT Staphylococcus aureus with varying virulence is often isolated from chronic rhinosinusitis (CRS) patients and impacts disease severity. Prophage‐mediated virulence, particularly encoded by φSa3int (NM3) prophages, which often encodes human immune‐evasion cluster genes is well known, but how a new prophage domestication impacts overall expression of core bacterial genes, and the expression of resident...

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PMID: 40787069
DOI: 10.1002/mco2.70313

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