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Article

Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis.

The Journal of biological chemistry - 13 Feb 2004

Tombline Gregory, Bartholomew Lori, Gimi Khursheed, Tyndall Grace A, Senior Alan E

Abstract excerpt

Functional roles of the two ABC signature sequences ("LSGGQ") in the N- and C-terminal nucleotide binding domains of P-glycoprotein were studied by mutating the conserved Ser residues to Ala. The two single mutants (S528A; S1173A) each impaired ATPase activity mildly, and showed generally symmetrical effects on function, consistent with equivalent mechanistic roles of the two nucleotide sites. Synergy between the...

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Identifiers

PMID: 14638679
DOI: 10.1074/jbc.M311964200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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