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Article

Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis.

The Journal of biological chemistry - 13 Feb 2004

Tombline Gregory, Bartholomew Lori, Gimi Khursheed, Tyndall Grace A, Senior Alan E

Abstract excerpt

Functional roles of the two ABC signature sequences ("LSGGQ") in the N- and C-terminal nucleotide binding domains of P-glycoprotein were studied by mutating the conserved Ser residues to Ala. The two single mutants (S528A; S1173A) each impaired ATPase activity mildly, and showed generally symmetr...

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PMID: 14638679
DOI: 10.1074/jbc.M311964200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14638679-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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