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Article

Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors.

Cancer research - 1 Jan 1999

Biegel J A, Zhou J Y, Rorke L B, Stenstrom C, Wainwright L M, Fogelgren B

Abstract excerpt

We examined 18 atypical teratoid and rhabdoid tumors of the brain and 7 renal and 4 extrarenal rhabdoid tumors for mutations in the candidate rhabdoid tumor suppressor gene, INI1. Fifteen tumors had homozygous deletions of one or more exons of the INI1 gene, and the other 14 tumors demonstrated mutations. Germ-line mutations of INI1 were identified in four children, one with an atypical teratoid tumor of the...

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PMID: 9892189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors.PMID 9892189Read ↗

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Loss of INI1 protein expression defines a subgroup of aggressive central nervous system primitive neuroectodermal tumors.Semantic proximity Read ↗

Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system.Semantic proximity Read ↗

INI1 Protein Expression Distinguishes Atypical Teratoid/Rhabdoid Tumor from Choroid Plexus CarcinomaSemantic proximity Read ↗

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