Article
Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes.
Biochemical and biophysical research communications - 21 Nov 2003
Ku Man-ching, Stewart Shavonne, Hata Akiko
Abstract excerpt
OAZ is a multi zinc finger protein which interacts with several distinct nuclear proteins including Olf-1/EBF, Smad1, and Smad4 and regulates transcription of various genes. Here we show that poly(ADP-ribose) polymerase 1 (Parp1) forms a complex with OAZ and positively regulates BMP-target genes, Xenopus Vent-2 and mouse Smad6 genes. Both wild type and the mutant forms of Parp1, which is deficient in...
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