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Article

In vivo reduction of amyloid-beta by a mutant copper transporter.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 2003

Phinney Amie L, Drisaldi Bettina, Schmidt Stephen D, Lugowski Stan, Coronado Veronica, Liang Yan, Horne Patrick, Yang Jing, Sekoulidis Joannis, Coomaraswamy Janaky, Chishti M Azhar, Cox Diane W, Mathews Paul M, Nixon Ralph A, Carlson George A, St George-Hyslop Peter, Westaway David

Abstract excerpt

Cu ions have been suggested to enhance the assembly and pathogenic potential of the Alzheimer's disease amyloid-beta (Abeta) peptide. To explore this relationship in vivo, toxic-milk (txJ) mice with a mutant ATPase7b transporter favoring elevated Cu levels were analyzed in combination with the transgenic (Tg) CRND8 amyloid precursor protein mice exhibiting robust Abeta deposition. Unexpectedly, TgCRND8 mice...

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Share to Amyloid beta-Protein Precursor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14617772
DOI: 10.1073/pnas.2332851100
PMCID: PMC283568

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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