Article
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 2003
Bayer Thomas A, Schäfer Stephanie, Simons Andreas, Kemmling André, Kamer Thomas, Tepest Ralf, Eckert Anne, Schüssel Katrin, Eikenberg Oliver, Sturchler-Pierrat Christine, Abramowski Dorothee, Staufenbiel Matthias, Multhaup Gerd
Abstract excerpt
The Cu-binding beta-amyloid precursor protein (APP), and the amyloid Abeta peptide have been proposed to play a role in physiological metal regulation. There is accumulating evidence of an unbalanced Cu homeostasis with a causative or diagnostic link to Alzheimer's disease. Whereas elevated Cu levels are observed in APP knockout mice, APP overexpression results in reduced Cu in transgenic mouse brain. Moreover,...
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