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Article

Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation.

International journal of oncology - 1 Dec 2003

Fraenzer Juergen-Theodor, Pan Huiqi, Minimo Lauro, Smith George M, Knauer Dan, Hung Gene

Abstract excerpt

The loss of NF2 gene function leads to vestibular nerve schwannoma formation in humans. The NF2 gene product, Merlin/Schwannomin, has recently been found to interact with the two PDZ domains containing protein EBP50/NHE-RF, which is itself known to interact with the PDGF receptor (PDGFR) in sever...

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PMID: 14612918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14612918-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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