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Article

Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide.

ACS chemical biology - 15 Sept 2017

Filipuzzi Ireos, Thomas Jason Ray, Pries Verena, Estoppey David, Salcius Michael, Studer Christian, Schirle Markus, Hoepfner Dominic

Abstract excerpt

The microbial metabolite Chivosazole F has been described to affect the cytoskeleton and to inhibit actin polymerization in vitro. Applying orthogonal genomic and proteomics approaches, we now show for the first time that Chivosazole F exerts its effect by directly interacting with actin and demonstrate the cellular impact of Chivosazole F in an unbiased, genome-wide context in yeast and in mammalian cells....

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Identifiers

PMID: 28796488
DOI: 10.1021/acschembio.7b00385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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