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A Ferret Model of Canine Distemper Virus Virulence and Immunosuppression

10 Nov 2003

Abstract excerpt

Canine distemper virus (CDV) infects many carnivores, including ferrets and dogs, and is the member of the Morbillivirus genus most easily amenable to experimentation in a homologous small-animal system. To gain insights into the determinants of CDV pathogenesis, we isolated a strain highly virulent for ferrets by repeated passaging in these animals. Sequence comparison of the genome of this strain with that of...

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PMID: 14610181
DOI: 10.1128/jvi.77.23.12579-12591.2003

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