Article
Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression.
The Journal of biological chemistry - 20 Feb 2004
Ghoshal Kalpana, Majumder Sarmila, Datta Jharna, Motiwala Tasneem, Bai Shoumei, Sharma Sudarshana M, Frankel Wendy, Jacob Samson T
Abstract excerpt
The methylation status of the CpG island located within the ribosomal RNA (rRNA) promoter in human hepatocellular carcinomas and pair-matched liver tissues was analyzed by bisulfite genomic sequencing. Significant hypomethylation of methyl-CpGs in the rRNA promoter was observed in the tumor samples compared with matching normal tissues, which was consistent with the relatively high level of rRNA synthesis in...
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