Article
Polymorphisms in genes of the endothelin system and cerebral small-vessel disease.
Stroke - 1 Aug 2005
Gormley Kelly, Bevan Steve, Hassan Ahamad, Markus Hugh S
Abstract excerpt
BACKGROUND AND PURPOSE: Endothelial dysfunction has been implicated in the pathogenesis of cerebral small-vessel disease (SVD). Endothelin (ET), released by the endothelium, plays a crucial role in vasoconstriction in the cerebral circulation and could contribute to the pathogenesis of cerebral SVD. Circulating ET levels may not reflect vascular production of endothelin-1 (ET-1), most of which is abluminal....
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