Article
Defensins from insects and plants interact with fungal glucosylceramides.
The Journal of biological chemistry - 6 Feb 2004
Thevissen Karin, Warnecke Dirk C, François Isabelle E J A, Leipelt Martina, Heinz Ernst, Ott Claudia, Zähringer Ulrich, Thomma Bart P H J, Ferket Kathelijne K A, Cammue Bruno P A
Abstract excerpt
Growth of the yeast species Candida albicans and Pichia pastoris is inhibited by RsAFP2, a plant defensin isolated from radish seed (Raphanus sativus), at micromolar concentrations. In contrast, gcs-deletion mutants of both yeast species are resistant toward RsAFP2. GCS genes encode UDP-glucose:ceramide glucosyltransferases, which catalyze the final step in the biosynthesis of the membrane lipid glucosylceramide....
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