Article
Glucosylceramide synthase is essential for alfalfa defensin-mediated growth inhibition but not for pathogenicity of Fusarium graminearum.
Molecular microbiology - 1 Nov 2007
Ramamoorthy Vellaisamy, Cahoon Edgar B, Li Jia, Thokala Mercy, Minto Robert E, Shah Dilip M
Abstract excerpt
Antifungal defensins, MsDef1 and MtDef4, from Medicago spp., inhibit the growth of a fungal pathogen, Fusarium graminearum, at micromolar concentrations. However, molecular mechanisms by which they inhibit the growth of this fungus are not known. We have characterized a functional role of the fungal sphingolipid glucosylceramide in regulating sensitivity of the fungus to MsDef1 and MtDef4. A null mutation of the...
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