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An inhibitor of glucosylceramide synthase inhibits the human enzyme, but not enzymes from other organisms.

Bioscience, biotechnology, and biochemistry - 1 Sept 2005

Hillig Inga, Warnecke Dirk, Heinz Ernst

Abstract excerpt

Specific inhibitors of glucosylceramide biosynthesis are used as drugs for the treatment of some human diseases correlated to glycosphingolipid metabolism. The target of the presently available inhibitors is the human glucosylceramide synthase (GCS), but effects on enzymes from other organisms have not been studied. We expressed cDNAs encoding GCS enzymes from lower animals, plants, fungi, and bacteria in the...

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PMID: 16195602
DOI: 10.1271/bbb.69.1782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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