Article
Age-dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein beta3 subunit as predictors of response to fluoxetine and nortriptyline.
The international journal of neuropsychopharmacology - 1 Dec 2003
Joyce Peter R, Mulder Roger T, Luty Suzanne E, McKenzie Janice M, Miller Allison L, Rogers Geraldine R, Kennedy Martin A
Abstract excerpt
In 169 depressed patients randomized to treatment with either fluoxetine or nortriptyline, we examined whether polymorphisms of the serotonin transporter and the G protein beta3 subunit influenced response to these antidepressants. For depressed patients under the age of 25 yr the T allele of the G protein beta3 subunit was associated with a markedly poorer response to nortriptyline, while serotonin transporter...
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