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Article

WT1 is a modifier of the Pax2 mutant phenotype: cooperation and interaction between WT1 and Pax2.

Oncogene - 6 Nov 2003

Discenza Maria Teresa, He Shujie, Lee Tae Ho, Chu Lee Lee, Bolon Brad, Goodyer Paul, Eccles Michael, Pelletier Jerry

Abstract excerpt

Metanephric kidney development requires an inductive interaction between the ureteric bud and progenitor mesenchyme, where the early expression of two genes, Wilms' tumour 1 (WT1) and paired box 2 (Pax2), establishes critical but unknown developmental pathways. Indeed, transgenic mice with deregulated overexpression of Pax2 exhibit structural kidney defects and impaired renal function, as do mice harboring...

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PMID: 14603255
DOI: 10.1038/sj.onc.1206997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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WT1 is a modifier of the Pax2 mutant phenotype: cooperation and interaction between WT1 and Pax2.PMID 14603255Read ↗

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