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Article

Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency.

The New England journal of medicine - 6 Nov 2003

Dadi Harjit K, Simon Amos J, Roifman Chaim M

Abstract excerpt

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Share to B-Lymphocytes
Share to CD3 Complex
Share to Consanguinity
Share to Fatal Outcome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Receptors, Antigen, T-Cell, gamma-delta

Share to Severe Combined Immunodeficiency

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Source

Identifiers

PMID: 14602880
DOI: 10.1056/NEJMoa031178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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Research trail→

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Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency.PMID 14602880Read ↗

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Differential biological role of CD3 chains revealed by human immunodeficiencies.Semantic proximity Read ↗

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Jak3 and the pathogenesis of severe combined immunodeficiency.Semantic proximity Read ↗

Different composition of the human and the mouse γδ T cell receptor explains different phenotypes of CD3γ and CD3δ immunodeficienciesSemantic proximity Read ↗

The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.Semantic proximity Read ↗

CD3 deficiencies.Semantic proximity Read ↗

Development of autologous, oligoclonal, poorly functioning T lymphocytes in a patient with autosomal recessive severe combined immunodeficiency caused by defects of the Jak3 tyrosine kinase.Semantic proximity Read ↗

Brief report: primary immunodeficiency caused by mutations in the gene encoding the CD3-gamma subunit of the T-lymphocyte receptor.Semantic proximity Read ↗

CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage.Semantic proximity Read ↗

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