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Article

STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis.

The Journal of biological chemistry - 13 Feb 2004

Townsend Paul A, Scarabelli Tiziano M, Davidson Sean M, Knight Richard A, Latchman David S, Stephanou Anastasis

Abstract excerpt

The STAT-1 transcription factor has been implicated as a tumor suppressor by virtue of its ability to inhibit cell growth and promoting apoptosis. However, the mechanisms by which STAT-1 mediates these effects remain unclear. Using human and mouse STAT-1-deficient cells, we show here that STAT-1 is required for optimal DNA damage-induced apoptosis. The basal level of the p53 inhibitor Mdm2 is increased in...

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Source

Identifiers

PMID: 14602726
DOI: 10.1074/jbc.M302637200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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