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Article

Thymic function and immunoglobulin mutation genotype in B-cell chronic lymphocytic leukemia patients.

International journal of cancer - 20 Dec 2003

Nardini Elena, Neri Francesca, Vicenzi Elisa, Poli Guido, Capello Daniela, Gaidano Gianluca, Vitolo Umberto, Ménard Sylvie, Balsari Andrea

Abstract excerpt

B-cell chronic lymphocytic leukemia (B-CLL) is characterized by a profound dysregulation of the host's immune system at both the humoral and cellular level. We investigated to see if this dysregulation could be due partly to thymus dysfunction by quantifying the number of signal joint T-cell receptor excision circles (sjTRECs) in peripheral blood mononuclear cells of 30 untreated B-CLL patients at diagnosis and...

Read the complete abstract on PubMed

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Share to Genes, Immunoglobulin
Share to Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Receptors, Antigen, T-Cell

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Share to T-Lymphocytes

Share to Thymus Gland

Source

Identifiers

PMID: 14601055
DOI: 10.1002/ijc.11482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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