Article

What are housekeeping genes?

2021-02-16

Abstract excerpt

The concept of “housekeeping genes” has been used for four decades but remains loosely defined. Housekeeping genes are commonly described as “essential for cellular existence regardless of their specific function in the tissue or organism”, and “stably expressed irrespective of tissue type, developmental stage, cell cycle state, or external signal”. However, experimental support for the tenet that gene essentialit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6114d008-a6e7-595b-beed-cc3ad3132116
DOI: 10.1101/2021.02.14.431149

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

What are housekeeping genes?DOI 10.1101/2021.02.14.431149Read

Redefining Housekeeping Genes in the Context of Vertebrate DevelopmentSemantic proximity Read

Divergent and convergent evolution of housekeeping genes in human-pig lineageSemantic proximity Read

HRT Atlas v1.1 database: redefining human and mouse housekeeping genes and candidate reference transcripts by mining massive RNA-seq datasetsSemantic proximity Read

Evaluating stably expressed genes in single cellsSemantic proximity Read

Mammalian housekeeping genes evolve more slowly than tissue-specific genes.Semantic proximity Read

Whole-body gene expression atlas of an adult metazoanSemantic proximity Read

Deciphering the Sex Bias in Housekeeping Gene Expression in Adipose Tissue: a Comprehensive Meta-analysis of Transcriptomic StudiesSemantic proximity Read

Assessing tissue-specific gene expression of essential genes from human and mouseSemantic proximity Read

Further understanding human disease genes by comparing with housekeeping genes and other genes.Semantic proximity Read

Assessment of Sex Bias in Housekeeping Gene Expression in Adipose Tissue Through the Massive Analysis of Transcriptomics DataSemantic proximity Read

Expanding the concept of housekeeping genes: Examining the influence of retroelements on gene expression stability during cellular differentiationSemantic proximity Read

A compendium of gene expression in normal human tissues.Semantic proximity Read