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Article

[The biological effect of the phosphatidylinositol 3-kinase wortmannin following thermal neutron irradiation].

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica - 1 Sept 2003

Kinashi Yuko, Masunaga Shinichiro, Suzuki Minoru, Nagata Kenji, Ono Koji

Abstract excerpt

PURPOSE: Wortmannin, a phosphatidylinositol 3-kinase inhibitor, has been found to inhibit DNA-dependent protein kinase (DNA-PKcs) and to be an efficient radiosensitizer. We investigated the radiosensitizing effect of wortmannin on cell killing by thermal neutrons and the occurrence of mutations at the HPRT locus of CHO cells. MATERIALS AND METHODS: Wortmannin was added to cells at a final concentration of 20...

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PMID: 14587410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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