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Article

DNA-PK: the Major Target for Wortmannin-mediated Radiosensitization by the Inhibition of DSB Repair via NHEJ Pathway.

1 Jan 2003

Abstract excerpt

The effect of wortmannin posttreatment was studied in cells derived from different species (hamster, mouse, chicken, and human) with normal and defective DNA-dependent protein kinase (DNA-PK) activity, cells with and without the ataxia telangiectasia (ATM) gene, and cells lacking other regulatory proteins involved in the DNA double-strand break (DSB) repair pathways. Clonogenic assays were used to obtain all...

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PMID: 13678345
DOI: 10.1269/jrr.44.151

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