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Article

Inhibition of Spermatogonial Differentiation by Testosterone

4 Mar 2003

Abstract excerpt

In this review we describe a variety of pathological conditions in rodents that result in seminiferous tubule atrophy, and which are characterized by the absence of all germ cells except for type A spermatogonia. In many such cases, suppression of gonadotropins and testosterone with gonadotropin-releasing hormone (GnRH) analogues restores spermatogonial differentiation and spermatogenic progression. In some...

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PMID: 12634296
DOI: 10.1002/j.1939-4640.2003.tb02652.x

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