Article
Human telomerase reverse transcriptase-specific T-helper responses induced by promiscuous major histocompatibility complex class II-restricted epitopes.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2003
Schroers Roland, Shen Lei, Rollins Lisa, Rooney Cliona M, Slawin Kevin, Sonderstrup Grete, Huang Xue F, Chen Si-Yi
Abstract excerpt
An effective tumor vaccine may require the induction of both CTL and T-helper (Th) cell responses against tumor-associated antigens. Human telomerase reverse transcriptase (hTERT) is highly expressed in >85% of cancer cells and thus is a potential target for tumor vaccines. We therefore sought to identify promiscuous Th epitopes in hTERT, which can be presented by more than one MHC class II allele. Each of 10...
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