Article
Sequential administration of the native TERT572 cryptic peptide enhances the immune response initiated by its optimized variant TERT(572Y) in cancer patients.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000
Vetsika Eleni-Kyriaki, Papadimitraki Elisavet, Aggouraki Despoina, Konsolakis Georgios, Mela Marina-Eleni, Kotsakis Athanasios, Christou Soultana, Patramani Stefania, Alefantinou Marina, Kaskara Ageliki, Christophyllakis Charalampos, Kosmatopoulos Kostas, Georgoulias Vassilis, Mavroudis Dimitris
Abstract excerpt
The aim of this study was to investigate the best administration of telomerase reverse transcriptase (TERT572), an human leukocyte antigen-A*0201-restricted cryptic epitope of telomerase, and its optimized variant TERT(572Y) to elicit specific T cell immune responses in cancer patients. Forty-eig...
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