Article
Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2004
Vonderheide Robert H, Domchek Susan M, Schultze Joachim L, George Daniel J, Hoar Kara M, Chen Dih-Yih, Stephans Katherine F, Masutomi Kenkichi, Loda Massimo, Xia Zhinan, Anderson Karen S, Hahn William C, Nadler Lee M
Abstract excerpt
PURPOSE: High-level expression of the telomerase reverse transcriptase (hTERT) in >85% of human cancers, in contrast with its restricted expression in normal adult tissues, points to hTERT as a broadly applicable molecular target for anticancer immunotherapy. CTLs recognize peptides derived from hTERT and kill hTERT+ tumor cells of multiple histologies in vitro. Moreover, because survival of hTERT+ tumor cells...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.