Article
The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 May 2013
Elliott Jayne L, Der Perng Ming, Prescott Alan R, Jansen Karin A, Koenderink Gijsje H, Quinlan Roy A
Abstract excerpt
CRYAB (αB-crystallin) is expressed in many tissues and yet the R120G mutation in CRYAB causes tissue-specific pathologies, namely cardiomyopathy and cataract. Here, we present evidence to demonstrate that there is a specific functional interaction of CRYAB with desmin intermediate filaments that predisposes myocytes to disease caused by the R120G mutation. We use a variety of biochemical and biophysical...
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