The effect of disease penetrance, family size, and age of onset on family history with application to setting eligibility criteria for genetic testing.

Abstract excerpt

The concept of family history of disease has been used as a surrogate for genetic susceptibility in many epidemiological studies and has also been important as a criterion for selecting individuals for genetic testing. However, little is known about the precise interplay between the true genetic model (genotype-specific penetrances, age of onset distribution), life expectancy, and reproductive patterns in...

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