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The Latency-Related Gene of Bovine Herpesvirus 1 Inhibits Programmed Cell Death

1 Dec 1999

Abstract excerpt

Although viral gene expression occurs in the peripheral nervous system during acute infection, bovine herpesvirus 1 (BHV-1) gene expression is extinguished, many neurons survive, and latency ensues. The only abundant viral transcript expressed during latency is the latency-related (LR) RNA, which is alternatively spliced in trigeminal ganglia during acute infection (L. Devireddy and C. Jones, J. Virol....

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PMID: 10559283
DOI: 10.1128/jvi.73.12.9734-9740.1999

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The Latency-Related Gene of Bovine Herpesvirus 1 Inhibits Programmed Cell DeathPMID 10559283Read ↗

The latency-related gene of bovine herpesvirus 1 encodes a product which inhibits cell cycle progressionSemantic proximity Read ↗

Functional analysis of bovine herpesvirus 1 (BHV-1) genes expressed during latency.Semantic proximity Read ↗

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A Bovine Herpesvirus 1 Protein Expressed in Latently Infected Neurons (ORF2) Promotes Neurite Sprouting in the Presence of Activated Notch1 or Notch3Semantic proximity Read ↗

A Mutation in the Latency-Related Gene of Bovine Herpesvirus 1 Leads to Impaired Ocular Shedding in Acutely Infected CalvesSemantic proximity Read ↗

Infection of cattle with a bovine herpesvirus 1 strain that contains a mutation in the latency-related gene leads to increased apoptosis in trigeminal ganglia during the transition from acute infection to latency.Semantic proximity Read ↗

Regulation of the latency-reactivation cycle by products encoded by the bovine herpesvirus 1 (BHV-1) latency-related gene.Semantic proximity Read ↗

Bovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1) Promote Survival of Latently Infected Sensory Neurons, in Part by Inhibiting ApoptosisSemantic proximity Read ↗

The bovine herpesvirus-1 LR ORF2 is critical for this gene's ability to restore the high wild-type reactivation phenotype to a herpes simplex virus-1 LAT null mutant.Semantic proximity Read ↗

Identification of a novel protein encoded by the latency-related gene of bovine herpesvirus 1.Semantic proximity Read ↗

Localization of sequences in a protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 that inhibits apoptosis and interferes with Notch1-mediated trans-activation of the bICP0 promoter.Semantic proximity Read ↗

A mutation in the latency-related gene of bovine herpesvirus 1 disrupts the latency reactivation cycle in calves.Semantic proximity Read ↗

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