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An experimental platform for studying growth and invasiveness of tumor cells within teratomas derived from human embryonic stem cells

22 Oct 2003

Abstract excerpt

There is currently no available experimental system wherein human cancer cells can be grown in the context of a mixed population of normal differentiated human cells for testing biological aspects of cancer cell growth (e.g., tumor cell invasion and angiogenesis) or response to anti-cancer therapies. When implanted into immunocompromised mice, human embryonic stem cells develop teratomas containing complex...

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PMID: 14573705
DOI: 10.1073/pnas.2235551100

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