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Article

Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells.

Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2008

Postovit Lynne-Marie, Margaryan Naira V, Seftor Elisabeth A, Kirschmann Dawn A, Lipavsky Alina, Wheaton William W, Abbott Daniel E, Seftor Richard E B, Hendrix Mary J C

Abstract excerpt

Embryonic stem cells sustain a microenvironment that facilitates a balance of self-renewal and differentiation. Aggressive cancer cells, expressing a multipotent, embryonic cell-like phenotype, engage in a dynamic reciprocity with a microenvironment that promotes plasticity and tumorigenicity. However, the cancer-associated milieu lacks the appropriate regulatory mechanisms to maintain a normal cellular...

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Identifiers

PMID: 18334633
DOI: 10.1073/pnas.0800467105
PMCID: PMC2393795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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