Article
Growth rate regulation of lac operon expression in Escherichia coli is cyclic AMP dependent.
FEBS letters - 23 Oct 2003
Kuo Jong-Tar, Chang Yu-Jen, Tseng Ching-Ping
Abstract excerpt
In contrast to the ribosomal RNA gene expression increasing with growth rate, transcription of the lac operon is downregulated by cell growth rate. In continuous culture, growth rate regulation of lac promoter was independent of carbon substrate used and its location on the chromosome. Since the lac operon is activated by cyclic adenosine monophosphate (cAMP), which decreases with increasing cell growth rate,...
Topics
- Bacteriophages
- Carbon
- Cyclic AMP
- Cyclic AMP Receptor Protein
- Escherichia coli
- Gene Deletion
- Gene Expression Regulation
- Genotype
- Guanosine Tetraphosphate
- Lac Operon
- Mutation
- Phenotype
- Plasmids
- Species Specificity
- Transcription, Genetic
- beta-Galactosidase