Article
Mechanism of the down-regulation of cAMP receptor protein by glucose in Escherichia coli: role of autoregulation of the crp gene.
The EMBO journal - 1 Jul 1994
Ishizuka H, Hanamura A, Inada T, Aiba H
Abstract excerpt
Glucose causes catabolite repression by lowering the intracellular levels of both cAMP and cAMP receptor protein (CRP) in Escherichia coli. The molecular mechanism underlying the down-regulation of CRP by glucose has been investigated. We show that glucose lowers the level of crp mRNA without aff...
Topics
- Base Sequence
- Binding Sites
- Cyclic AMP
- Cyclic AMP Receptor Protein
- Down-Regulation
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Glucose
- Models, Biological
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- RNA, Bacterial
- RNA, Messenger
- Transcription, Genetic
- Transcriptional Activation