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Article

Alzheimer's disease skin fibroblasts selectively express a bradykinin signaling pathway mediating tau protein Ser phosphorylation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2003

Jong Yuh-Jiin I, Ford Stephanie R, Seehra Kuljeet, Malave Victor Brian, Baenziger Nancy Lewis

Abstract excerpt

Increased Ser phosphorylation of tau microtubule-associated protein in the brain is an early feature of Alzheimer's disease (AD) that precedes progression of the disease to frank neuronal disruption. We demonstrate that bradykinin (BK) B2 receptor activation leads to selective Ser phosphorylation of tau in skin fibroblasts from persons who have or will develop AD due to Presenilin 1 mutations or Trisomy 21, but...

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Identifiers

PMID: 14563691
DOI: 10.1096/fj.02-1147fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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