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Article

Evidence of reciprocal tertiary interactions between conserved motifs involved in organizing RNA structure essential for internal initiation of translation.

RNA (New York, N.Y.) - 1 Feb 2006

Fernández-Miragall Olga, Ramos Ricardo, Ramajo Jorge, Martínez-Salas Encarnación

Abstract excerpt

Internal ribosome entry site (IRES) elements consist of highly structured RNA regions that determine internal initiation of translation. We have previously shown that the foot-and-mouth disease virus (FMDV) IRES contains a GNRA tetraloop spanning residues G178UAA181. Here we show that tertiary RNA interactions dependent on the GNRA motif determine the structural organization of the central domain. By using...

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Identifiers

PMID: 16373480
DOI: 10.1261/rna.2153206
PMCID: PMC1370902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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