A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype hypothesis.

doi:10.1038/sj.npp.1301121

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Article

A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype hypothesis.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2006

Levitan Robert D, Masellis Mario, Lam Raymond W, Kaplan Allan S, Davis Caroline, Tharmalingam Subi, Mackenzie Bronwyn, Basile Vincenzo S, Kennedy James L

Abstract excerpt

We have recently described an association between the hypofunctional 7-repeat allele (7R) of the dopamine-4 receptor gene (DRD4), weight gain, and obesity in women with seasonal affective disorder (SAD). In the current study, we examined whether season-of-birth might interact with the 7R allele to influence body weight regulation in SAD. In 182 female probands with SAD, we performed an analysis of covariance...

Topics

Adolescent
Adult
Aged
Analysis of Variance
Body Mass Index
Chi-Square Distribution
Female
Genetic Predisposition to Disease
Humans
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Minisatellite Repeats

Obesity

Predictive Value of Tests

RNA, Messenger

Receptors, Dopamine D4

Reverse Transcriptase Polymerase Chain Reaction

Seasonal Affective Disorder

Seasons

Source

Open in PubMed

Identifiers

PMID: 16760922
DOI: 10.1038/sj.npp.1301121

Genes

DRD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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