Article
A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype hypothesis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2006
Levitan Robert D, Masellis Mario, Lam Raymond W, Kaplan Allan S, Davis Caroline, Tharmalingam Subi, Mackenzie Bronwyn, Basile Vincenzo S, Kennedy James L
Abstract excerpt
We have recently described an association between the hypofunctional 7-repeat allele (7R) of the dopamine-4 receptor gene (DRD4), weight gain, and obesity in women with seasonal affective disorder (SAD). In the current study, we examined whether season-of-birth might interact with the 7R allele to influence body weight regulation in SAD. In 182 female probands with SAD, we performed an analysis of covariance...
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