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Article

Synthesis of a novel histidine analogue and its efficient incorporation into a protein in vivo.

Protein engineering - 1 Sept 2003

Ikeda Yutaka, Kawahara Shun-ichi, Taki Masumi, Kuno Atsushi, Hasegawa Tsunemi, Taira Kazunari

Abstract excerpt

Proteins containing unnatural amino acids have immense potential in biotechnology and medicine. We prepared several histidine analogues including a novel histidine analogue, beta-(1,2,3-triazol-4-yl)-DL-alanine. These histidine analogues were assayed for translational activity in histidine-auxotrophic Escherichia coli strain UTH780. We observed that several histidine analogues, including our novel histidine...

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Identifiers

PMID: 14560056
DOI: 10.1093/protein/gzg084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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