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Article

Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients.

Human genetics - 1 Dec 2003

McCarthy Jeanette J, Meyer Joanne, Moliterno David J, Newby L Kristin, Rogers William J, Topol Eric J

Abstract excerpt

Major genetic determinants of the metabolic syndrome - a clustering of abdominal obesity, high triglycerides, low HDL cholesterol, high blood pressure and high fasting glucose - remain elusive. We surveyed 207 single-nucleotide polymorphisms in 110 candidate genes among coronary artery disease patients, a population enriched for metabolic abnormalities. The number of abnormalities (0-5) was determined in the 214...

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Source

Identifiers

PMID: 14557872
DOI: 10.1007/s00439-003-1026-1

Genes

ACAT2
GBE1
ITGB3
LDLR
LIPC
LRPAP1
PRCP
SELE
SELP
TGFB1
THBS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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