Article
Interaction of hemoglobin E and several forms of alpha-thalassemia in Cambodian families.
Haematologica - 1 Oct 2003
Fucharoen Supan, Sanchaisuriya Kanokwan, Fucharoen Goonnapa, Panyasai Sitthichai, Devenish Robyn, Luy Lyda
Abstract excerpt
BACKGROUND AND OBJECTIVES: This study aimed to describe hematologic and molecular characterization of the interaction of hemoglobin (Hb) E and several forms of alpha-thalassemia causing complex thalassemia syndromes in two Cambodian families as well as to establish a rapid polymerase chain reaction (PCR) assay for simultaneous detection of Hb Constant Spring (CS) and Hb Pakse' (PS). DESIGN AND METHODS: Using PCR...
Topics
- Adolescent
- Adult
- Alleles
- Cambodia
- Child
- Child, Preschool
- DNA Mutational Analysis
- Female
- Hemoglobin E
- Hemoglobins, Abnormal
- Humans
- Male
- Middle Aged
- Mutation
- Pedigree
- Polymerase Chain Reaction
- Protein Interaction Mapping
- Protein Isoforms