Article
Sox6 regulation of cardiac myocyte development.
Nucleic acids research - 15 Oct 2003
Cohen-Barak Orit, Yi Zanhua, Hagiwara Nobuko, Monzen Koshiro, Komuro Issei, Brilliant Murray H
Abstract excerpt
A mouse mutation (p100H/p100H) has been identified that is associated with cardioskeletal myopathy, heart block, delayed growth and early postnatal death. The gene that is disrupted in this mutation encodes the transcription factor Sox6. P19CL6 cells were used as an in vitro cardiomyocyte differentiation system and revealed that Sox6 is expressed exclusively when the cells are committed to differentiate to...
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