Article
A one-step real-time PCR assay for rapid prenatal diagnosis of sickle cell disease and detection of maternal contamination.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology - 1 Jan 2003
Costa Catherine, Pissard Serge, Girodon Emmanuelle, Huot Danièle, Goossens Michel
Abstract excerpt
INTRODUCTION: Mutations at the codon 6 of the beta-globin gene (hemoglobin [Hb] S and HbC) can be routinely identified by various methods and prenatal diagnosis has been available to affected families for several years. However, the presence of maternal cells in fetal samples constitutes a serious potential source of prenatal misdiagnosis and most methods currently used to detect maternal contamination are based...
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