Article
A simple VNTR-PCR method for detecting maternal cell contamination in prenatal diagnosis.
Genetic testing - 1 Jan 1998
Batanian J R, Ledbetter D H, Fenwick R G
Abstract excerpt
The effectiveness of variable number tandem repeats (VNTRs) was evaluated in the detection of maternal cell contamination. Nonradioactive PCRs were performed on 30 sets of prenatal tissue using VNTRs as primers. The combination of two VNTRs (YNZ22 and APOB) provided information on all 30 cases, distinguishing maternal-fetal genotype patterns and detecting maternal cell contamination in 5 of 30 prenatal cases. The...
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