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Genetics of the human Y chromosome and its association with male infertility

17 Feb 2018

Abstract excerpt

The human Y chromosome harbors genes that are responsible for testis development and also for initiation and maintenance of spermatogenesis in adulthood. The long arm of the Y chromosome (Yq) contains many ampliconic and palindromic sequences making it predisposed to self-recombination during spermatogenesis and hence susceptible to intra-chromosomal deletions. Such deletions lead to copy number variation in...

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PMID: 29454353
DOI: 10.1186/s12958-018-0330-5

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