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Article

Protein tyrosine phosphatase 1B participates in the down-regulation of erythropoietin receptor signalling.

The Biochemical journal - 15 Jan 2004

Cohen Jacob, Oren-Young Liat, Klingmuller Ursula, Neumann Drorit

Abstract excerpt

Erythropoietin (EPO) is the principal hormone regulating the proliferation of erythroid precursors and their differentiation into erythrocytes. Binding of ligand to the cell-surface EPO-R (EPO receptor) induces dimerization and JAK2 (Janus kinase 2)-mediated tyrosine phosphorylation of the receptor. Less than 1% of the EPO-Rs are displayed on the cell surface; most of the receptor molecules are retained in...

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Source

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Identifiers

PMID: 14527337
DOI: 10.1042/BJ20031420
PMCID: PMC1223869

Genes

EPO
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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