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Article

Thalamic control of visceral nociception mediated by T-type Ca2+ channels.

Science (New York, N.Y.) - 3 Oct 2003

Kim Daesoo, Park Donghyun, Choi Soonwook, Lee Sukchan, Sun Minjeong, Kim Chanki, Shin Hee-Sup

Abstract excerpt

Sensations from viscera, like fullness, easily become painful if the stimulus persists. Mice lacking alpha1G T-type Ca2+ channels show hyperalgesia to visceral pain. Thalamic infusion of a T-type blocker induced similar hyperalgesia in wild-type mice. In response to visceral pain, the ventroposterolateral thalamic neurons evokeda surge of single spikes, which then slowly decayed as T type-dependent burst spikes...

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Source

Identifiers

PMID: 14526084
DOI: 10.1126/science.1088886

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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