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Article

Telomeres as targets for anticancer therapies

3 Feb 2011

Abstract excerpt

INTRODUCTION: The limitless replicative potential of cancer cells relies on telomere integrity (which is guaranteed by a complex interaction between several specialized proteins and telomeric DNA) and the activation of specific mechanisms for telomere length maintenance. Two mechanisms are currently known in human cancer, namely telomerase activity and the alternative lengthening of telomere pathway. EXPERT...

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Share to DNA and Nucleic Acid Chemistry
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PMID: 21288186
DOI: 10.1517/14728222.2011.556621

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