Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola.

doi:10.1101/gad.1137303

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Article

Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola.

Genes & development - 15 Oct 2003

Horiuchi Takayuki, Giniger Edward, Aigaki Toshiro

Abstract excerpt

longitudinals lacking (lola) is a complex Drosophila gene encoding at least 20 protein isoforms,each bearing the same N-terminal constant region linked to a different C-terminal variable region. Different isoforms specify different aspects of axon growth and guidance. We show here that lola mRNAs are generated by alternative trans-splicing of exons sequentially encoded by the same DNA strand. Chromosomal pairing...

Topics

Alternative Splicing
Animals
Drosophila
Drosophila Proteins
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Protein Isoforms
Sequence Analysis, DNA
Transcription Factors

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Identifiers

PMID: 14522953
DOI: 10.1101/gad.1137303
PMCID: PMC218142

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