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Article

Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola.

Genes & development - 15 Oct 2003

Horiuchi Takayuki, Giniger Edward, Aigaki Toshiro

Abstract excerpt

longitudinals lacking (lola) is a complex Drosophila gene encoding at least 20 protein isoforms,each bearing the same N-terminal constant region linked to a different C-terminal variable region. Different isoforms specify different aspects of axon growth and guidance. We show here that lola mRNAs are generated by alternative trans-splicing of exons sequentially encoded by the same DNA strand. Chromosomal pairing...

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Identifiers

PMID: 14522953
DOI: 10.1101/gad.1137303
PMCID: PMC218142

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Source receipt: pubmed, retrieved 7 Sept 2026.

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