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Article

Genetic analysis in Leber's hereditary optic neuropathy using the comparative genomic hybridization technique.

Clinical & experimental ophthalmology - 1 Oct 2003

Yen May-Yung, Chen Yann-Jang, Lin Chi-Hung, Wang An-Guor, Wei Yau-Huei

Abstract excerpt

BACKGROUND: Nuclear genes are suggested to be involved in the pathogenesis of Leber's hereditary optic neuropathy (LHON) but it has not been confirmed. The aim of the present study was to investigate chromosomal abnormalities associated with LHON. METHODS: In a prospective study, comparative genomic hybridization (CGH) was used to analyse genetic changes in five patients with LHON with an 11778 mitochondrial DNA...

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Identifiers

PMID: 14516433
DOI: 10.1046/j.1442-9071.2003.00692.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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