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Article

Evaluation of the X-linked modifier loci for Leber hereditary optic neuropathy with the G11778A mutation in Chinese.

Molecular vision - 11 Mar 2010

Ji Yanli, Jia Xiaoyun, Li Shiqiang, Xiao Xueshan, Guo Xiangming, Zhang Qingjiong

Abstract excerpt

PURPOSE: To test the association of the X-chromosome regions (Xp21.1-q21.2 and Xq25-27.2) with Leber hereditary optic neuropathy (LHON) in Chinese patients. METHODS: One hundred and seventy-five male LHON patients with the G11778A mutation and 100 unrelated normal males participated. Twelve microsatellite markers and four single-nucleotide polymorphisms (SNPs) were genotyped for patients and controls. A chi(2) or...

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PMID: 20300564
PMCID: PMC2838738

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